Histamine dihydrochloride
Ceplene (histamine dihydrochloride) is a small molecule pharmaceutical. Histamine dihydrochloride was first approved as Histamine phosphate on 1982-01-01. It is used to treat allergic rhinitis seasonal and urticaria in the USA. It has been approved in Europe to treat myeloid leukemia acute.
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rhinitis | D012220 | EFO_0008521 | J31 | 14 | 42 | 90 | 78 | 28 | 248 |
| Allergic rhinitis | D065631 | — | J30.9 | 13 | 40 | 84 | 76 | 24 | 233 |
| Healthy volunteers/patients | — | — | — | 106 | 2 | 3 | 5 | 16 | 130 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | 4 | 24 | 43 | 34 | 11 | 115 |
| Conjunctivitis | D003231 | HP_0000509 | H10 | 1 | 8 | 31 | 26 | 5 | 70 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | 2 | 8 | 29 | 27 | 5 | 70 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 13 | 19 | 6 | 8 | 17 | 62 |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | 2 | 5 | 24 | 17 | 5 | 52 |
| Depression | D003863 | — | F33.9 | 2 | 12 | 3 | 16 | 15 | 47 |
| Urticaria | D014581 | EFO_0005531 | L50 | 3 | 6 | 17 | 14 | 6 | 45 |
Show 192 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 6 | 10 | 3 | — | 3 | 18 |
| Lymphoma | D008223 | — | C85.9 | 4 | 10 | 2 | — | 2 | 17 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 7 | 2 | — | — | 12 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 7 | 2 | — | — | 12 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 2 | — | 9 | 12 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | 1 | 2 | 6 | — | 1 | 9 |
| Communicable diseases | D003141 | — | — | 1 | 4 | 2 | — | 3 | 9 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | 1 | — | 1 | 8 |
| Respiratory tract infections | D012141 | — | J06.9 | 1 | 1 | 5 | — | 2 | 8 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | 3 | 1 | — | 1 | 7 |
Show 111 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 4 | 8 | — | — | 1 | 11 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 2 | 8 | — | — | 1 | 11 |
| Recurrence | D012008 | — | — | 2 | 5 | — | — | 2 | 8 |
| Hepatitis b | D006509 | — | — | 1 | 6 | — | — | — | 7 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | 6 | — | — | — | 7 |
| Body weight | D001835 | EFO_0004338 | — | — | 6 | — | — | 1 | 7 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 2 | — | — | 2 | 6 |
| Disease | D004194 | EFO_0000408 | R69 | 2 | 1 | — | — | 4 | 6 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 3 | — | — | — | 6 |
| Alcohol drinking | D000428 | EFO_0004329 | — | 1 | 5 | — | — | — | 6 |
Show 164 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 4 | — | — | — | 2 | 6 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 3 | 4 |
| Fasting | D005215 | EFO_0002756 | — | 3 | — | — | — | — | 3 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | 1 | — | — | — | 2 | 3 |
| Biological availability | D001682 | — | — | 3 | — | — | — | — | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | 1 | 2 |
| Alcohol-related disorders | D019973 | — | F10 | 1 | — | — | — | 1 | 2 |
| Hyperalgesia | D006930 | — | — | 1 | — | — | — | 1 | 2 |
| Food-drug interactions | D018565 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Histamine release | D006636 | — | — | — | — | — | — | 10 | 10 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 5 | 5 |
| Necrosis | D009336 | — | — | — | — | — | — | 4 | 4 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | — | 4 | 4 |
| Sleep deprivation | D012892 | — | F51.12 | — | — | — | — | 4 | 4 |
| Digestive system diseases | D004066 | HP_0011024 | K92.9 | — | — | — | — | 4 | 4 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | — | 4 | 4 |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | — | — | 3 | 3 |
| Morphine dependence | D009021 | EFO_0005612 | — | — | — | — | — | 3 | 3 |
| Benign paroxysmal positional vertigo | D065635 | — | — | — | — | — | — | 3 | 3 |
Show 105 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Histamine dihydrochloride |
| INN | — |
| Description | Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cl.Cl.NCCc1c[nH]cn1 |
Identifiers
| PDB | — |
| CAS-ID | 56-92-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1533310 |
| ChEBI ID | — |
| PubChem CID | 5818 |
| DrugBank | — |
| UNII ID | — |
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10 adverse events reported
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